I hope you like my spider Dont worry it will not bite.Running a registry cleaner is good for speeding your computer up when it has slowed down Ccleaner is a good free one.You can pick it up here
 When Spyware Hits you hard and You need a good cleanup Try Malwarebytes Antimalware If you run this or your antispyware that you have in safe mode it helps to get rid of these pests better Becaust only the most needed software and drivers are loaded. To get  in Safe mode reboot your Computer and before windows starts hold down the F8 key on you keyboard when you see a menu use your arrow keys go up untll you get to safe mode then click on it your machine will boot up in safe mode select yes i know it is running in safe mode. Then When your Icons Show up on your desktop Select the Antspyware you want to run when its done cleaning reboot and run Ccleaner to clean up your Registry Then Defrag  using  Auslogics Disk defrag or Whatever You Use to Defrag Your Hard Drive.Its A good Idea To Run a few differant Antispyware Programs to make sure your system is cleaned up Never use one That pops up on some sites these are sometimes Rouge Programs Malwarebytes Has a list of Rouge Programs On There Site Check That Out First To Be Safe!